多囊性卵巢與隱藏性糖尿病具相當程度關聯

高達36%之PCO(多囊性卵巢)印度女性呈現血糖耐受力異常
其中6%呈現明顯糖尿病

PCO 與隱藏性糖尿病具相當程度關聯

http://www.ncbi.nlm.nih.gov/pubmed/26407537

冷凍載具比較

冷凍載具比較
cryoloop 溫度速度遠大於其他載具

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660183/

Comparison of the “closed” Rapid-i carrier to the “open” cryoloop. Diagram illustrates the two carriers, properties and compares cooling /warming rates.

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8-cell比2-cell期胚胎具更高冷凍存活率

經玻璃化冷凍後, 8-cell期胚胎比2-cell期胚胎具更高存活率

試管懷孕流產8成原因為胚胎染色體異常

試管懷孕流產最常見原因為胚胎染色體異常(占82%)
尤其是胚胎染色體3套數之異常(占83%)
染色體最常見之異常為15,16,18,21,22染色體

Fertil Steril. 2015 Sep 7. pii: S0015-0282(15)01761-6. doi: 10.1016/j.fertnstert.2015.08.007. [Epub ahead of print]

Embryo selection versus natural selection: how do outcomes of comprehensive chromosome screening of blastocysts compare with the analysis of products of conception from early pregnancy loss (dilation and curettage) among an assisted reproductive technology population?

Rodriguez-Purata J1, Lee J2, Whitehouse M2, Moschini RM2, Knopman J3, Duke M2, Sandler B3, Copperman A3.

Author information

Abstract

OBJECTIVE:

To compare the incidence of numerical chromosomal abnormalities (NCAs) reported after preimplantation genetic screening (PGS) analysis compared with that reported after cytogenetic analysis of products of conception after spontaneous abortion.

DESIGN:

Retrospective study.

SETTING:

Private academic in vitro fertilization center.

PATIENT(S):

Cytogenetic reports of patients who underwent an IVF cycle with PGS of at least one biopsied embryo were compared with cytogenetic analysis reported from patients who had dilation and curettage (D&C) for the treatment of a spontaneous abortion after assisted reproductive technology (ART) treatment.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Frequencies for each numerical chromosomal abnormality from both groups were compared.

RESULT(S):

A total of 1,069 NCAs were reported after PGS (trisomy 54.3%, monosomy 45.7%, no polyploidies), resulting in a trisomy/monosomy ratio of 0.82. A total of 447 NCAs was reported after D&C (trisomy 83%, polyploidy 10.7%, monosomy 6.3%). The aneuploidies most frequently identified were similar in both groups and included 15, 16, 18, 21, and 22. Monosomies (n = 28, 6.3%) were rarely observed in the group that underwent D&C after ART.

CONCLUSION(S):

This review provides an analysis of the most commonly identified NCAs after PGS and in first-trimester D&C samples in an infertile population utilizing ART. Although monosomies comprised >50% of all cytogenetic anomalies identified after PGS, there were very few identified in the post-D&C samples. This suggests that although monosomies occur frequently in the IVF population, they commonly do not implant. Despite this difference, this study demonstrated that the specific NCAs observed after PGS analysis and D&C were comparable.

高齡病患卵針劑劑量450 vs 600 iu 懷孕率無明顯差異

針對高齡反應差poor responder之病患
高劑量誘導排卵針劑劑量450 iu vs 600 iu
懷孕率(16 vs18)&取卵數(4 vs 4)無明顯差異

Fertil Steril. 2015 Sep 7. pii: S0015-0282(15)01851-8. doi: 10.1016/j.fertnstert.2015.08.014. [Epub ahead of print]

450 IU versus 600 IU gonadotropin for controlled ovarian stimulation in poor responders: a randomized controlled trial.

Lefebvre J1, Antaki R2, Kadoch JI2, Dean NL3, Sylvestre C4, Bissonnette F2, Benoit J4, Ménard S2, Lapensée L2.

Author information

Abstract

OBJECTIVE:

To compare the outcomes of controlled ovarian stimulation/in vitro fertilization cycles using 450 IU and 600 IU gonadotropin per day in women at risk of poor ovarian response.

DESIGN:

Prospective randomized controlled nonblinded study.

SETTING:

University-affiliated private IVF center.

PATIENT(S):

Women considered to be at risk of poor ovarian response: aged <41 years with basal FSH >10 IU/L, antimüllerian hormone <1 ng/mL, antral follicle count ≤8, or a previous IVF cycle with ≥300 IU/d gonadotropin that resulted in a cancellation, <8 follicles, or <5 oocytes.

INTERVENTION(S):

A total of 356 patients underwent a microdose GnRH agonist flare-up IVF/intracytoplasmic sperm injection protocol with a fixed daily dose of either 450 IU FSH (n = 176) or 600 IU FSH (n = 180) equally divided between Menopur and Bravelle.

MAIN OUTCOME MEASURE(S):

Number of mature oocytes retrieved.

RESULT(S):

The two groups were similar in terms of age, ovarian reserve, cause of infertility, duration of stimulation, and cycle cancellation rate. There were no significant differences in the number of metaphase II oocytes retrieved (4 [range 0-6] vs. 4 [range 2-7]), fertilization rate (62.4% vs. 57.0%), biochemical pregnancy rate (20.5% vs. 22.9%), clinical pregnancy rate (16.4% vs. 18.3%), and implantation rate (29.8% vs. 30.4%) between the 450 IU and 600 IU groups, respectively.

CONCLUSION(S):

Gonadotropin of 600 IU/d does not improve outcome of IVF cycles compared with 450 IU/d in women at risk of poor ovarian response.