Hum Reprod. 2018 Aug 8. doi: 10.1093/humrep/dey259. [Epub ahead of print]
Type of underwear worn and markers of testicular function among men attending a fertility center.
Mínguez-Alarcón L1, Gaskins AJ2,3, Chiu YH2,3, Messerlian C1, Williams PL3,4, Ford JB1, Souter I5, Hauser R1,3,6, Chavarro JE2,3,7.
Abstract
STUDY QUESTION:
Is self-reported type of underwear worn associated with markers of testicular function among men at a fertility center?
SUMMARY ANSWER:
Men who reported most frequently wearing boxers had higher sperm concentration and total count, and lower FSH levels, compared to men who did not.
WHAT IS KNOWN ALREADY:
Elevated scrotal temperatures are known to adversely affect testicular function. However, the epidemiologic literature on type of underwear, as a proxy of scrotal temperature, and male testicular function is inconsistent.
STUDY DESIGN, SIZE, DURATION:
This is a cross-sectional study including 656 male partners of couples seeking infertility treatment at a fertility center (2000-2017).
PARTICIPANTS/MATERIALS, SETTING, METHODS:
Self-reported information on type of underwear worn was collected from a take-home questionnaire. Semen samples were analyzed following World Health Organization guidelines. Enzyme immunoassays were used to assess reproductive hormone levels and neutral comet assays for sperm DNA damage. We fit linear regression models to evaluate the association between underwear type and testicular function, adjusting for covariates and accounting for multiple semen samples.
MAIN RESULTS AND THE ROLE OF CHANCE:
Men had a median (interquartile range) age of 35.5 (32.0, 39.3) years and BMI of 26.3 (24.4, 29.9) kg/m2. About half of the men (53%; n = 345) reported usually wearing boxers. Men who reported primarily wearing boxers had a 25% higher sperm concentration (95% CI = 7, 31%), 17% higher total count (95% CI = 0, 28%) and 14% lower serum FSH levels (95% CI = -27, -1%) than men who reported not primarily wearing boxers. Sperm concentration and total count were inversely related to serum FSH. Furthermore, the differences in sperm concentration and total count according to type of underwear were attenuated after adjustment for serum FSH. No associations with other measured
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