PGS應用是否能提高累積懷孕率與年齡有關

對於>35歲以上較能提高懷孕率，主因在於囊胚染色體異常率較高

年輕<35歲病患因為囊胚染色體異常率較低 ，PGS對於提高累積懷孕率較無明顯影響

Success rates with preimplantation genetic testing for aneuploidy in good prognosis patients are dependent on age

https://www.fertstert.org/article/S0015-0282(24)02261-1/abstract

To evaluate cumulative live birth after preimplantation genetic testing for aneuploidy (PGT-A) with next generation sequencing (NGS) compared with morphology alone among patients aged 21–40 years undergoing single blastocyst transfer.

• A total of 56,469 retrieval cycles were included in the analysis. Retrieval cycles were stratified based on age (<35, 35–37, and 38–40 years) and exposure to PGT-A with NGS. 
• the use of PGT-A was associated with a slightly lower cumulative live birth in individuals aged <35 years (risk ratio [RR]: 0.96; 95% CI: 0.93–0.99) compared with no PGT, 
• but higher cumulative live birth in ages 35–37 years (RR: 1.04; 95% CI: 1.00–1.08), 
• and 38–40 years (RR: 1.14; 95% CI: 1.07–1.20). 
• PGT-A was associated with higher cumulative live birth in individuals aged ≥35 years 
• was similar to no PGT in individuals aged <35 years. 
• Miscarriage was significantly less likely in individuals aged ≥35 years using PGT-A compared with no PGT-A.