Day4 胚胎可能尚無自我修復染色體之能力

Day4胚胎有高比例之染色體異常(>50%)

Day4前胚胎可能尚無自我修復染色體之能力

胚胎自我修復染色體之能力可能始自Day5囊胚期

http://humrep.oxfordjournals.org/content/28/6/1716.abstract

17%囊胚期胚胎同時兼具正常與異常染色體

PGD顯示，17%囊胚期胚胎同時兼具正常與異常染色體
這些胚胎仍可能發展成正常胚胎

囊胚期胚胎PGD並非全然準確

Of more significance may be the 17% of blastocysts that contained both diploid and aneuploid cells. The fate of these embryos is unclear. It is possible that the aneuploid cells have a growth disadvantage or are eliminated by processes such as apoptosis, leading to a decline in their numbers as development progresses, ultimately resulting in a normal fetus. If this scenario is correct, some diploid–aneuploid mosaic blastocysts may be viable and might be incorrectly discarded if aneuploid cells were detected following TE biopsy. 

http://humrep.oxfordjournals.org/content/26/2/480.full

植入胚胎有百分之30在著床後12天內流產

植入胚胎有30%順利活產

植入胚胎有30%完全未著床
植入胚胎有30%在著床後12天內流產
植入胚胎有10%在著床後12天後流產

懷孕早期流產有72%染色體異常

http://humupd.oxfordjournals.org/content/8/4/333.full.pdf+html

植入前胚胎染色體有高度不穩定性

植入前胚胎染色體有高度不穩定性，包括
染色體缺損，多套染色體，etc

http://www.ncbi.nlm.nih.gov/pubmed/19396175?dopt=Abstract

3-D sona 於胚胎植入

使用3-D sona 於胚胎植入

http://www.jultrasoundmed.org/content/28/5/573.full

COH劑量150iu vs 225iu 臨床結果類似

非高齡誘導排卵啟始劑量150iu vs 225iu
取卵數&胚胎數較少，但臨床結果類似

http://humupd.oxfordjournals.org/content/17/2/184.full

囊胚期植入子宮收縮頻率明顯下降

囊胚期植入(hCG打後第7天)比Day2胚胎植入(hCG打後第4天)
子宮收縮頻率明顯下降(1.5 contractions/min vs 3.5 contractions/min) 

http://humrep.oxfordjournals.org/content/16/6/1115.long

Day2 vs Day5誘導排卵抽血結果類似

Day2 或 Day5誘導排卵其抽血結果類似，
Day5誘導排卵卵泡數量少於 Day2誘導排卵

http://jcem.endojournals.org/content/96/4/1122.full

低劑量COH懷孕率較一般劑量COH為低

低劑量誘導排卵COH之試管嬰兒IVF療程懷孕率較一般劑量IVF療程為低
(18 vs 29%)

http://humrep.oxfordjournals.org/content/25/11/2678.full

IVF取卵數理想數量為15顆

取卵數15顆為理想數量，
可達最佳懷孕率，
並不提高卵巢過度刺激風險




http://humrep.oxfordjournals.org/content/26/7/1768.full

Laser可提高囊胚冷凍之存活率

玻璃化冷凍前，施行囊胚雷射輔助孵化可提高囊胚冷凍之存活率

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114962/?report=reader

封閉式vs開放式冷凍載具胚胎存活率類似

玻璃化冷凍載具可分封閉式vs開放式，二者胚胎存活率類似

http://www.ncbi.nlm.nih.gov/pubmed/23315263

紫外光可應用於防止冷凍過程病毒傳染

紫外光可殺死液態氮中之病毒
可應用於防止冷凍過程病毒傳染

http://humrep.oxfordjournals.org/content/24/11/2969.long

Letrozole對於懷孕胚胎早期骨骼發育有不良影響

Letrozole對於懷孕胚胎早期骨骼發育有不良影響
Letrozole抑制cytochrome P450 enzyme aromatase  &抑制estrogen生成

http://humrep.oxfordjournals.org/content/24/11/2688.full