植入前胚胎染色體有高度不穩定性

植入前胚胎染色體有高度不穩定性，包括
染色體缺損，多套染色體，etc

http://www.ncbi.nlm.nih.gov/pubmed/19396175?dopt=Abstract

Nat Med. 2009 May;15(5):577-83. doi: 10.1038/nm.1924. Epub 2009 Apr 26.

Chromosome instability is common in human cleavage-stage embryos.

Vanneste E1, Voet T, Le Caignec C, Ampe M, Konings P, Melotte C, Debrock S, Amyere M, Vikkula M, Schuit F, Fryns JP, Verbeke G,D'Hooghe T, Moreau Y, Vermeesch JR.

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Abstract

Chromosome instability is a hallmark of tumorigenesis. This study establishes that chromosome instability is also common during early human embryogenesis. A new array-based method allowed screening of genome-wide copy number and loss of heterozygosity in single cells. This revealed not only mosaicism for whole-chromosome aneuploidies and uniparental disomies in most cleavage-stage embryos but also frequent segmental deletions, duplications and amplifications that were reciprocal in sister blastomeres, implying the occurrence of breakage-fusion-bridge cycles. This explains the low human fecundity and identifies post-zygotic chromosome instability as a leading cause of constitutional chromosomal disorders.