2014年12月20日

hCG100-150iu誘導排卵可達不錯IVF懷孕率

IVF誘導排卵COH配合FSH+hCG100-150iu可達不錯懷孕率

http://humrep.oxfordjournals.org/content/27/10/3074.full



A randomized controlled dose–response pilot study of addition of hCG to recombinant FSH during controlled ovarian stimulation for in vitro fertilization


Table IV
Cycle outcome.
Dose 0 (n= 16)Dose 50 (n= 15)Dose 100 (n= 16)Dose 150 (n= 13)P-value
Treatment duration (days)10.3 ± 1.49.3 ± 1.49.9 ± 1.310.4 ± 1.10.14
Total dose of rFSH (IU)1538 ± 2091385 ± 2321475 ± 1951562 ± 1630.10
Patients reaching oocyte retrieval [n (%)]16 (100)15 (100)15 (94)13 (100)0.42
Oocytes retrieved/per retrieval9.3 ± 6.38.5 ± 4.49.2 ± 4.211.3 ± 5.70.53
Fertilization rate (%)a0.77 ± 0.270.72 ± 0.270.83 ± 0.230.67 ± 0.340.51
Cleavage rateb0.72 ± 0.270.66 ± 0.270.77 ± 0.230.60 ± 0.340.41
Patients with embryo transfer [n (%)]14 (88)14 (93)15 (94)10 (77)0.48
 Embryos transferred1.1 ± 0.271.1 ± 0.271.2 ± 0.411.0 ± 0.00.37*
 SETc [n (% per embryo transfer)]13 (93)13 (93)12 (80)10 (100)0.37
Total implantation rated (%)4/15 (27)4/15 (27)5/18 (28)4/10 (40)0.78
Patients with embryos cryopreserved8 (50)8 (53)12 (75)8 (62)0.48
 Cryopreserved embryos per patient2.8 ± 3.72.2 ± 2.62.8 ± 2.43.2 ± 3.40.87
Positive hCG/cycle started7 (44)5 (33)7 (44)5 (39)0.92
Clinical pregnancy/cycle started4 (25)4 (27)6 (38)4 (31)0.87
Live birthse/cycle started4 (25)4 (27)4 (25)4 (31)0.98
Number of FERf cycles6782
Positive hCG after FER/FER cycles1 (17)2 (29)4 (50)1 (50)0.57
Live births after FER (n)g1131
Cumulated no. of live birthsh/started ‘fresh cycle’5 (31)5 (33)7 (44)5 (39)0.89
  • Values are mean ± SD or number (column percentage). ANOVA or χ² test is used.
  • aOocytes fertilized per intact oocyte retrieved.
  • bMore than 1 cell Day 2 per intact oocyte aspirated.
  • cSingle embryo transfer.
  • dGestational sacs per embryos transferred.
  • eAll fresh transfers were singletons.

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