排卵日前P4濃度過高會影響人工受孕IUI懷孕率

排卵日前1.5日之P4濃度過高>1.1會影響人工受孕IUI懷孕率

http://www.ncbi.nlm.nih.gov/pubmed/26171998

Fertil Steril. 2015 Jul 11. pii: S0015-0282(15)00453-7. doi: 10.1016/j.fertnstert.2015.06.026. [Epub ahead of print]

Ongoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels.

Requena A1, Cruz M2, Pacheco A2, García-Velasco JA3.

Author information

Abstract

OBJECTIVE:

To determine the relationship between serum P levels on the day of hCG administration and ongoing pregnancy rates.

DESIGN:

Retrospective study.

SETTING:

University-affiliated private IVF setting belonging to IVI group in Spain.

PATIENT(S):

A total of 2,458 couples undergoing IUI.

INTERVENTION(S):

Ovarian stimulation with human recombinant FSH.

MAIN OUTCOME MEASURE(S):

Ongoing pregnancy and miscarriage rates.

RESULT(S):

Progesterone concentrations were significantly higher given that the E2 concentration increased. Ongoing pregnancy rates were significantly decreased in women with P levels higher than 1.1 ng/mL; similar results were obtained in relation to miscarriage rates.

CONCLUSION(S):

Significant differences in ongoing pregnancy rates when P levels were elevated on the day of hCG administration may help clinicians to counsel patients about the reduced success rates with IUI and manage the timing of insemination to optimize implantation.