子宮鏡檢查前12 h (vs 3 h)使用cytotec 2#塞於陰道可軟化子宮頸,下降疼痛

Fertil Steril. 2016 Mar 30. pii: S0015-0282(16)30055-3. doi: 10.1016/j.fertnstert.2016.03.022. [Epub ahead of print]

Optimal timing of misoprostol administration in nulliparous women undergoing office hysteroscopy: a randomized double-blind placebo-controlled study.

Fouda UM1, Gad Allah SH2, Elshaer HS2.

Author information

Abstract

OBJECTIVE:

To determine the optimal timing of vaginal misoprostol administration in nulliparous women undergoing office hysteroscopy.

DESIGN:

Randomized double-blind placebo-controlled study.

SETTING:

University teaching hospital.

PATIENT(S):

One hundred twenty nulliparous patients were randomly allocated in a 1:1 ratio to the long-interval misoprostol group or the short-interval misoprostol group.

INTERVENTION(S):

In the long-interval misoprostol group, two misoprostol tablets (400 μg) and two placebo tablets were administered vaginally at 12 and 3 hours, respectively, before office hysteroscopy. In the short-interval misoprostol group, two placebo tablets and two misoprostol tablets (400 μg) were administered vaginally 12 and 3 hours, respectively, before office hysteroscopy.

MAIN OUTCOME MEASURE(S):

The severity of pain was assessed by the patients with the use of a 100-mm visual analog scale (VAS). The operators assessed the ease of the passage of the hysteroscope through the cervical canal with the use of a 100-mm VAS as well.

RESULT(S):

Pain scores during the procedure were significantly lower in the long-interval misoprostol group (37.98 ± 13.1 vs. 51.98 ± 20.68). In contrast, the pain scores 30 minutes after the procedure were similar between the two groups (11.92 ± 7.22 vs. 13.3 ± 6.73). Moreover, the passage of the hysteroscope through the cervical canal was easier in the long-interval misoprostol group (48.9 ± 17.79 vs. 58.28 ± 21.85).

CONCLUSION(S):

Vaginal misoprostol administration 12 hours before office hysteroscopy was more effective than vaginal misoprostol administration 3 hours before office hysteroscopy in relieving pain experienced by nulliparous patients undergoing office hysteroscopy.