COH後之不成熟卵M1 冷凍存活率與成熟卵M2 冷凍存活率類似
(81.1% vs 85.2%)
未經COH之不成熟卵M1 冷凍後胚胎成熟至M2率遠低於成熟卵M2
(39.1 vs 73.3%)
Should metaphase 1 and 2 stages oocytes be vitrified in the same time for fertility preservation?
Sifer C1,2,3,
Sellam-Chokron O1,
Sermondade N1,
Cedrin-Durnerin I4,
Sonigo C2,4,
Herbemont C1,2,
Grynberg M2,4.
Abstract
AIMS:
Could metaphase 1 (M1) and 2 (M2) stages oocytes from in vitro maturation (IVM) cycles and controlled-ovarian hyperstimulation (COH) cycles be frozen at the same time without any adverse effect of vitrification on further survival (SR) and maturation rates (MR)?
MATERIALS & METHODS:
M1 from cancer patients were prospectively included in IVM/COH groups, and in study or control subgroups if they were vitrified or not. In each study subgroup, SR were compared with that of M2 oocytes vitrified/warmed from egg donors. MR were compared with those of fresh-M1 oocytes from control IVM/COH subgroups.
RESULTS:
SR were not different between groups. MR compared respectively between survived- and fresh-M1 oocytes were similar when resulting from COH (85.2 vs 81.1%) but significantly lower after IVM (39.1 vs 73.3%).
CONCLUSION:
Simultaneous freezing of M1/M2 oocytes could be applied to COH but not to IVM during the course of fertility preservation.
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