IVF使用GnRHantagonist抑制自發性排卵失敗率約1.6%, 好發於FSH較高卵巢功能較差病患
IVF使用GnRHagonist抑制自發性排卵失敗率約0.15%

Zhonghua Fu Chan Ke Za Zhi. 2016 May 25;51(5):352-6. doi: 10.3760/cma.j.issn.0529-567X.2016.05.006.

[Spontaneous ovulation in in vitro fertilization-embryo transfer cycles usinggonadotropin-releasing hormone antagonist: a large-sample retrospective study].

[Article in Chinese]

Luo L1, Chen MH, Jia MX, Wang Q, Zhou CQ.

Author information

Abstract

OBJECTIVE:

To investigate the premature spontaneous ovulation rates in in vitro fertilization-embryo transfer (IVF-ET) cycles using gonadotropin-releasing hormone antagonist (GnRH-ant) and gonadotropin-releasing hormoneagonist (GnRH-a), as well as the risk factors for premature spontaneous ovulation.

METHODS:

The rates of premature spontaneous ovulation in a total of 10 612 cycles using GnRH-ant or GnRH-a were compared. Matched case-controlled study and binary logistic regression model were conducted to analyze the risk factors for premature spontaneous ovulation.

RESULTS:

The spontaneous ovulation rate in the whole for GnRH-a cycles was 0.15% (13/8 514), compared with a 1.62% (34/2 098) in GnRH-ant cycles (P<0.01). Further matched controlled study and regression analyze found out that higher basal FSH level was a predominant risk and prediction factor for spontaneous ovulation (OR=1.20, P=0.009).

CONCLUSIONS:

In GnRH-ant cycles, spontaneous ovulation rate is about 10 times than which in GnRH-a cycles. Diminished ovarian function is a predominate risk factor for premature spontaneous ovulation.