AMH下降, 胚胎植入後流產率上升

Fertil Steril. 2017 Sep;108(3):518-524. doi: 10.1016/j.fertnstert.2017.07.001.

Serum antimüllerian hormone levels are independently related to miscarriage rates after in vitro fertilization-embryo transfer.

Tarasconi B1, Tadros T2, Ayoubi JM2, Belloc S2, de Ziegler D2, Fanchin R3.

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Abstract

OBJECTIVE:

To investigate whether serum antimüllerian hormone (AMH) levels are independently related to miscarriage rates after in vitro fertilization-embryo transfer (IVF-ET).

DESIGN:

Cohort study.

SETTING:

University-affiliated IVF-ET center.

PATIENT(S):

A total of 1,060 patients who attained a clinical pregnancy after IVF-ET.

INTERVENTIONS(S):

Centralized serum AMH measurements were performed within the 12 months before IVF-ET. Binary logistic regression was used to verify whether serum AMH levels were associated with the occurrence of a miscarriage independently from confounding factors, such as age and intensity of ovarian response to controlled ovarian stimulation assessed by the number of oocytes retrieved.

MAIN OUTCOME MEASURE(S):

Miscarriage rates.

RESULT(S):

In patients displaying reduced serum AMH levels, miscarriage rates were significantly increased independently from age and the number of oocytes retrieved.

CONCLUSION(S):

The present data indicate that serum AMH levels are independently associated with the occurrence of a miscarriage after IVF-ET.