Hum Reprod. 2018 Nov 8. doi: 10.1093/humrep/dey328. [Epub ahead of print]
Association between BMI and semen quality: an observational study of 3966 sperm donors.
Abstract
STUDY QUESTION:
What is the relationship between abnormal BMI and semen quality?
SUMMARY ANSWER:
Underweight was significantly associated with lower sperm concentration, total sperm number and total motile sperm count, while overweight was significantly associated with lower semen volume, total sperm number and total motile sperm count.
WHAT IS KNOWN ALREADY:
Abnormal BMI has been associated with lower semen quality, but the results remain somewhat controversial. In addition, most previous studies have focused on the influence of obesity or overweight on semen quality, and evidence on the association between underweight and semen quality is rare.
STUDY DESIGN, SIZE, DURATION:
This research was an observational study investigating 3966 sperm donors from a large sperm bank in Wuhan city, China. These donors passed the screening for sperm donation and underwent 29 949 semen examinations between 1 January 2013 and 9 April 2018.
PARTICIPANTS/MATERIALS, SETTING, METHODS:
BMI was categorized into four groups: underweight (<18.5 kg/m2), normal weight (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2) and obese (≥30 kg/m2). Semen volume, sperm concentration, total sperm number, total motility, progressive motility and total motile sperm count were determined by trained clinical technicians. Linear mixed models were used to conduct dose-response analyses between BMI and semen quality parameters.
MAIN RESULTS AND THE ROLE OF CHANCE:
Underweight was significantly associated with a 3.0% (95% CI: 0.1%, 5.8%), 6.7% (1.9%, 11.3%) and 7.4% (2.2%, 12.4%) reduction in sperm concentration, total sperm number and total motile sperm count, respectively. Overweight was significantly associated with a 4.2% (1.6%, 6.8%), 3.9% (0.9%, 6.9%) and 3.6% (0.2%, 6.9%) reduction in semen volume, total sperm number and total motile sperm count, respectively. Non-linear models including continuous BMI as a natural cubic spline function yielded similar results.
沒有留言:
張貼留言