受孕胚胎未超過9個，懷孕率與胚胎數量成正比
Fertil Steril. 2019 Sep;112(3):520-526.e1. doi: 10.1016/j.fertnstert.2019.04.023. Epub 2019 Jun 18.
Clinical pregnancy (CP) and live birth (LB) increase significantly with each additional fertilized oocyte up to nine, and CP and LB decline after that: an analysis of 15,803 first fresh in vitro fertilization cycles from the Society for Assisted Reproductive Technology registry.
Abstract
OBJECTIVE:
To study the association between the total number of fertilized oocytes available and pregnancy outcomes in first fresh IVF cycles with a single blastocyst transfer.
DESIGN:
Retrospective cohort study.
SETTING:
Not applicable.
PATIENT(S):
A total of 15,803 patients from SART reporting fertility clinics.
INTERVENTION(S):
None.
MAIN OUTCOME MEASURE(S):
Primary outcomes were clinical pregnancy (CP), live birth (LB), and miscarriage rates. Logistic regression was used to investigate the association between the number of fertilized eggs and each outcome.
RESULT(S):
The median number of total oocytes was 15, and the median number of fertilized oocytes was nine. The odds of a clinical pregnancy were 8% higher for each additional fertilized oocyte up to nine (odds ratio [OR] 1.08; 95% confidence interval [CI] 1.07-1.10) and declined by 9% for every additional fertilized oocyte after nine (OR 0.91; 95% CI 0.89-0.94). Similarly, the odds of an LB was 8% higher for every additional fertilized oocyte up to none (OR 1.08; 95% CI 1.06-1.10) and declined by 8% for every additional fertilized oocyte over nine (OR 0.92; 95% CI 0.90-0.94).
CONCLUSION(S):
Odds of pregnancy outcomes (CP, LB) increase significantly with every additional fertilized oocyte up to nine, and CP and LB decline after that in first fresh autologous cycles with a single blastocyst transfer.
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