子宮內注射HCG無法明顯提高IVF-ET胚胎著床懷孕率

Arch Gynecol Obstet. 2018 Dec;298(6):1061-1069. doi: 10.1007/s00404-018-4923-1. Epub 2018 Oct 5.

Effect of intrauterine injection of human chorionic gonadotropin before fresh embryo transfer on IVF and ICSI outcomes: a meta-analysis.

Hou W1, Shi G1, Cai B1, Ding C1, Song J1, Zhang X1, Xu Y2.

Author information

1

Reproductive Medical Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.

2

Reproductive Medical Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China. xuyanwen663000@126.com.

Abstract

PURPOSE:

This analysis was performed to evaluate the effects of intrauterine injection of human chorionic gonadotropin (hCG) before fresh embryo transfer (ET) on the outcomes of in vitro fertilization and intracytoplasmic sperm injection.

METHODS:

Randomized controlled trials (RCTs) were identified by searching electronic databases. The outcomes of live birth, clinical pregnancy, implantation, biochemical pregnancy, ongoing pregnancy, ectopic pregnancy, and miscarriage between groups with and without hCG injections were analyzed. Summary measures were reported as risk ratios (RR) with 95% confidence intervals.

RESULTS:

Six RCTs on fresh embryo transfer (ET) were included in the meta-analysis. A total of 2759 women undergoing fresh ET were enrolled (hCG group n = 1429; control group n = 1330). Intrauterine injection of hCG significantly increased rates of biochemical pregnancy (RR 1.61) and ongoing pregnancy (RR 1.58) compared to controls. However, there were no significant differences in clinical pregnancy (RR 1.11), implantation (RR 1.17), miscarriage (RR 0.91), ectopic (RR 1.65) or live birth rates (RR 1.13) between the hCG group and control group.

CONCLUSION:

The current evidence for intrauterine injection of hCG before fresh ET does not support its use in an assisted reproduction cycle.