D2凍胚解凍後培養24H再植入可能可提高懷孕率
Do different culture intervals (2 × 24 hours) after thaw of cleavage stage embryos affect pregnancy rates? A randomized controlled trial☆
Abstract
The aim of the study was to evaluate whether selecting embryos for transfer after prolonged culture after thaw (18–24 h) has better pregnancy rates than selecting embryos for transfer after short culture after thaw (2–5 h).
We performed a double-blinded, randomized, controlled trial, evaluating 388 patients submitted to ART treatment who had embryos frozen on day-2 and subsequently transferred. All patients received the same endometrial priming with estradiol valerate followed by vaginal progesterone. Patients were randomized for Frozen embryo transfer 2–5 h after thaw (Group D2) or 18–24 h after thaw (Group D2/D3). The main Outcome Measure was ongoing pregnancy rate (OPR) at 20 weeks' gestation per embryo transfer.
A total of 179 patients had embryos transferred 2–5 h after thaw and 209 patients had embryos transferred 18–24 h after thaw. The mean age in group D2 was 36 ± 4.4 and 36 ± 5.4 in group D2/D3. Ongoing pregnancy rate was 28% and 33.5% (p = 0.2) for groups D2 and D2/D3, respectively.
These results suggest that increasing the culture time of embryos in one day to improve selection before transfer does not increase ongoing pregnancy rate.
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