BMI體重差異與胚胎染色體異常比率無明顯關連

Body mass index is not associated with the number or proportion of aneuploid, mosaic, or euploid embryos per cycle in a large cohort of patients undergoing in vitro fertilization with preimplantation genetic testing for aneuploidy.

Fertility and Sterility 2021 VOLUME 116, ISSUE 2, P388-395

Yael R. Stovezky, B.A., Phillip A. Romanski, M.D., Pietro Bortoletto, M.D., Steven D. Spandorfer, M.D.

Objective

To assess the association between body mass index (BMI) and embryo aneuploidy and mosaicism in a cohort of patients undergoing in vitro fertilization (IVF) with trophectoderm biopsy for preimplantation genetic testing for aneuploidy (PGT-A) using next-generation sequencing technology.

Patients

Patients undergoing their first IVF cycle with trophectoderm biopsy and PGT-A at our center between January 1, 2017, and August 31, 2020. Patients classified as underweight on the basis of BMI (BMI <18.5 kg/m2) and patients who underwent fresh embryo transfers were excluded.

Main Outcome Measures

Number and proportion of aneuploid, mosaic, and euploid embryos.

Results

The patients were stratified according to the World Health Organization’s BMI classification: normal weight (18.5–24.9 kg/m2, n = 1,254), overweight (25–29.9 kg/m2, n = 351), and obese (≥30 kg/m2, n = 145). Age-adjusted regression models showed no relationship between BMI classification and the number or proportion of aneuploid embryos. There were no statistically significant associations between BMI classifications and the number or proportion of mosaic or euploid embryos. A subgroup analysis of patients classified into age groups of <35, 35–40, and >40 years similarly showed no relationships between BMI and embryo ploidy outcomes.

Conclusion

Body mass index was not associated with the number or proportion of aneuploid, mosaic, or euploid embryos in this large cohort of patients undergoing IVF with PGT-A, suggesting that the negative effect of excess weight on reproductive outcomes was independent of the ploidy status of the embryo cohort.