使用progestin(PPOS, duphaston 20mg/d) vs  GnRH antagonist 應用於試管誘導排卵之LH抑制 

PPOS 組和 GnRH antagonist的整倍體率相當（分別為 12.5% 和 16.0%，P > 0.05）。

兩組FET在每次移植的妊娠試驗陽性率、臨床懷孕率、流產率、子宮外孕率或活產率方面均無顯著差異。

Comparison of the euploidy rate  following progestin-primed vs GnRHantagonist protocol

• Euploidy rate was comparable between the PPOS and antagonist group (12.5% vs. 16.0% respectively, P > 0.05). 
• No significant differences were observed between the two groups in positive pregnancy test, clinical pregnancy, miscarriage, ectopic pregnancy, or live birth rates per transfer in the first frozen embryo transfer cycles.
• Both PPOS and antagonist protocols had similar euploidy rates in PGT-A cycles.

Variables	PPOS group (n = 120)	Antagonist group (n = 120)	P-value
Starting dose of FSH (IU)	225.0 (225.0-225.0)	225.0 (225.0-225.0)	0.134
Total dosage of FSH (IU)	1800.0 (1575.0-2025.0)	1800.0 (1575.0-2212.5)	0.010
Duration of stimulation (days)	8.0 (7.0-8.8)	8.0 (7.0–9.0)	0.053
Serum estradiol level on trigger day (pg/ml)	1870.5 (912.7-2940.1)	1061.3 (592.0-2614.1)	0.007
Serum LH level on trigger day (IU/l)	4.3 (2.7–5.9)	2.4 (1.6–3.6)	0.000
Serum progesterone level on trigger day (ng/ml)	0.9 (0.6–1.2)	0.8 (0.6–1.2)	0.588
Premature ovulation (%)	0.8 (1/120)	0.8 (1/120)	1
No. of retrieved oocytes (n)	6.0 (3.0–10.0)	5.0 (3.0–10.0)	0.914
No. of mature occytes (n)	4.5 (2.0–8.0)	4.0 (3.0–9.0)	0.980
No. of oocytes fertilized (n)	3.0 (2.0–7.0)	3.0 (2.0–6.0)	0.728
Fertilization rate (%)	94.4 (75.0-100)	92.9 (75.0-100)	0.746
Cleavage rate (%)	100 (100–100)	100 (100–100)	0.648
No. of blastocysts formation (n)	1.5 (0–3.0)	1.0 (0–3.0)	0.422
Blastocysts formation rate (%)	59.4 (33.3–100)	50.0 (33.3–80)	0.299
Total No. of euploid blastocysts	93	97
No. of euploid blastocysts (n)	0 (0–1.0)	0 (0–1.0)	0.995
Euploid blastocysts rate per injected oocyte (%)	12.5 (0–25.0)	16.0 (0-27.7)	0.477
Euploid blastocysts rate per woman (%)	33.3 (0-66.7)	50.0 (0-66.7)	0.459
No. of cycles with no blastocyst for biopsy (%)	27.5 (33/120)	30.0 (36/120)	0.669
No. of cycles with no euploid blastocysts for transfer (%)	52.5 (63/120)	55.0 (66/120)	0.698

PPOS group (n = 53)	Antagonist group (n = 47)	P-value
Endometrial preparation, n (%)			0.995
Natural cycles	1.9 (1/53)	2.0% (1/47)
Clomid-induced	11.5 (6/53)	10.0 (5/47)
Hormonal cycles	83.0 (44/53)	91.5 (43/47)
Endometrial thickness (day of trigger) (mm)	10.0 (8.6–11.0)	9.1 (8.5–10.4)	0.600
hCG test positive rate (%)	66.0 (35/53)	70.2 (33/47)	0.655
Clinical pregnancy rate (%)	58.5 (31/53)	59.6 (28/47)	0.912
Clinical miscarriage rate (%)	9.7 (3/31)	17.9 (5/28)	0.359
Ectopic pregnancy rate (%)	0 (0/35)	0 (0/33)	0
Live birth rate (%)	52.8 (28/53)	48.9 (23/47)	0.359

Back to article page