輔酶Q10是提高精子濃度最有效的治療方法

左旋肉鹼( Carnitine)是增強精子活力的最佳治療方法

Effects of Carnitine and Coenzyme Q10 on Sperm Quality and Pregnancy Rates in Men with Unexplained Infertility: A Systematic Review and Network Meta-Analysis

Aims

To study and explore the effects of oral Carnitine and Coenzyme Q10 on the quality of sperm and the rate of pregnancy in males with unexplained infertility.

Background

Preventing and reducing oxidative stress is essential for male infertility treatment. Antioxidants can effectively improve sperm quality and maintain sperm motility, thereby improving male fertility. At present, the most commonly used antioxidants in the clinic are carnitine and coenzyme Q10.

Methods

In this study, the effects of carnitine and coenzyme Q10 antioxidants on sperm quality and the rate of pregnancy in men with unexplained infertility were explored using a network meta-analysis method. The Cochrane Library, EMBASE, Web of Science and PubMed databases were searched for relevant studies. The observed indicators included semen concentration, progressive sperm motility, the rate of morphologically normal sperm and pregnancy rate.

Results

16 pieces of literature were included after rigorous screening. L-carnitine, coenzyme Q10 and L-carnitine + acetyl-L-carnitine significantly improved sperm quality parameters compared with placebo. CoQ10 induced the highest increase in sperm concentration (SMD 2.98 [95% CI: 1.13 to 7.87]). Furthermore, L-Carnitine has the greatest improvement effect on progressive sperm motility (SMD 4.19 [95% CI: 1.60 to 10.95]).

Conclusions

CoQ10 was the most effective intervention measure for improving sperm concentration, and L-carnitine was regarded as the best treatment method for enhancing sperm motility. In the future, we need more high-quality and large-sample studies to verify the effectiveness of antioxidants in the treatment of male infertility.