抗苗勒氏管激素 (AMH) 臨界值以確定多囊性卵巢形態
l 評估 AMH 臨界值
3.2 ng/mL 在經陰道超音波 (TVUS) 確定
PCOM 狀態的有效性。
l 根據血清AMH或陰道超音波(TVUS)檢測結果，計算PCOM陽性病例（PCOS表型為A、C或D的參與者）和陰性對照的數量。
l 3.2 ng/mL為AMH截斷值， AMH 3.2 ng/m用於檢測PCOM的高準確性。在所有PCOM陽性的PCOS表型和體質指數分類中，AMH與PCOM狀態也具有一致性
Anti-Müllerian hormone cutoff
to determine polycystic ovarian morphology: HARMONIA study
- To
verify the anti-Müllerian hormone (AMH) cutoff (3.2 ng/mL) for the
determination of polycystic ovarian morphology (PCOM) as part of the latest
polycystic ovary syndrome (PCOS) diagnosis in an independent prospective cohort
of women of reproductive age.
- Assessment of the performance of the AMH cutoff of 3.2
ng/mL to identify PCOM status determined by transvaginal ultrasound (TVUS).
- The number of PCOM-positive cases (participants with PCOS
phenotypes A, C, or D) and negative controls according to serum AMH or TVUS.
- Other measures included PCOM status within selected PCOS
phenotypes and demographic/clinical factors including body mass index.
- Applying the AMH cutoff of 3.2 ng/mL, 118 of 128 cases and
639 of 820 controls were identified in accordance with TVUS (overall percent
agreement, 79.9%).
- Agreement of AMH with PCOM status was also observed across
all PCOM-positive PCOS phenotypes and body mass index categories.
- Conclusion
- The Elecsys AMH Plus immunoassay cutoff of 3.2 ng/mL was
successfully verified, showing high accuracy to detect PCOM.
- On the basis of current guideline recommendations for the
detection of PCOM as part of PCOS diagnosis, these data support use of the AMH
test as an easy-access diagnostic workup tool compared with TVUS.
沒有留言:
張貼留言