2026年4月27日

胚胎移植前子宮腔內注射人類絨毛膜促性腺激素(hCG)不太可能提高活產率或其他生育結果。

不論HCG施打劑量 時機 成分 凍胚或鮮胚等各種變因,均無明顯差異

dosage of hCG (500 IU vs ≥500 IU)

type of hCG (urinary hCG vs recombinant)

injection timing (on day of ET vs ≥2 days before ET)

transfer method (fresh vs frozen), 

Intrauterine human chorionic gonadotropin administration before embryo transfer (IHABT): an individual participant data meta-analysis of randomized controlled trials Open Access

Published:
 
16 April 2026 

Intrauterine administration of hCG before embryo transfer is unlikely to improve live birth rate or other fertility outcomes in individuals undergoing IVF, with low-moderate evidence available. We did not identify any patient subgroup that would benefit from the intervention. The differences between evidence from RCTs with and without IPD were likely due to major concerns about the trustworthiness of RCTs without IPD. Therefore, intrauterine hCG before embryo transfer should not be offered as an IVF add-on in clinical practice.



embryo transfer stage (cleavage vs blastocyst). s

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