GnRH antagonist抑制子宮內膜雌激素與黃體素接受體

GnRH antagonist可能會抑制子宮內膜之雌激素與黃體素接受體 (estrogen receptor & progesterone receptor之mRNA expression)

著床窗口 implantation 約為LH上升後第5-10天
window of implantation is described as from Day 5 to Day 10 after the LH surge (Sharkey and Smith, 2003).

http://humrep.oxfordjournals.org/content/22/11/2981.full

卵巢不佳病患優先考慮GnRHantagonist COH療程

卵巢反應不佳之病患可優先考慮使用GnRHantagonist COH療程

GnRHantagonist COH療程較GnRHagonist 短


http://humrep.oxfordjournals.org/content/26/10/2742.full

卵巢功能不佳誘導排卵優先考慮GnRHantagonist

卵巢功能不佳之病患施行試管&誘導排卵，優先考慮GnRHantagonist
GnRHantagonist優於GnRHa短療程

http://www.sciencedirect.com/science/article/pii/S0015028213031099

腦下垂體拮抗劑誘導排卵HCG 施打時機

使用腦下垂體拮抗劑gonadotropin-releasing hormone antagonists施行試管嬰兒誘導排卵，HCG 施打時機3顆卵子>1.6cm當天施打HCG(early-hCG group)
3顆卵子>1.6cm後24h施打HCG (late-hCG group)
二組懷孕率&活產率 無統計差異
較早施打HCG 並沒較好之臨床效果