玻尿酸篩選精蟲方法與教學

玻尿酸(hyaluronan hydrogel. Hyaluronan)篩選精蟲方法與教學
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PICSITM Sperm Selection Device Biocoat's PICSI Sperm Selection Device offers significant advantages in selecting sperm for the ICSI (Intra Cytoplasmic Sperm Injection) method of in vitro fertilization. In the ICSI procedure, an individual sperm is selected and injected into a oocyte. Until now, the only technique available to embryologists to select the sperm has been visual observation. With Biocoat new PICSI Sperm Selection Device embryologists are able to determine sperm selection in much the same way it happens in human biology. Sperm is placed in Biocoat laboratory PICSI dish containing samples of hyaluronan hydrogel. Hyaluronan is a naturally occurring biopolymer found in all human cells, including the gel layer surrounding the oocyte. Mature, biochemically competent sperm bind to the hyaluronan where they can be isolated by the embryologist and used for ICSI. The Biocoat device actually mimics a key step in the natural fertilization process, the binding of mature sperm to the oocyte complex. As a result, the selected sperm is essentially the same as one that would be successful in the natural reproductive process. Dr. Gabor Huszar of the Yale University School of Medicine is the inventor of the PICSI technique. His research proved that hyaluronan-bound PICSI-selected sperm are, in the vast majority of cases, more mature, exhibit less DNA damage, and have fewer chromosomal aneuploidies. In the long run it is thought that the use of the new PICSI technique should improve pregnancy rates and reduce the number of IVF miscarriages. Albert J. Peters, D.O., F.A.C.O.G., stated, "We believe that the PICSI device could have significant clinical importance to our ICSI patients." Indications for Use: In the treatment of infertile couples by ICSI, PICSI is indicated for the selection of mature sperm for injection. Regulatory The PICSI Sperm Selection Device is cleared for marketing under Section 510(k) by the U.S. Food & Drug Administration and has received the CE-mark. ISO Certification Biocoat, Inc. is certified under the ISO 13485:2003 standard. View certificate (pdf file) HBA?Sperm-Hyaluronan Binding Assay The HBA Sperm-Hyaluronan Binding Assay is an important new tool for urologists, sperm banks, embryologists, fertility clinics that can be used to diagnose previously unexplained male infertility and to select the best course of treatment when Assisted Reproductive Technologies (ART) is indicated. The HBA assay makes it possible to by-pass in vitro fertilization (IVF) in cases where the lack of mature sperm predicts that approach would be unproductive. In those cases, one can move earlier to other techniques, such as intracytoplasmic sperm injection (ICSI) avoiding needless and unproductive IVF cycles which are burdensome, cost up to $10,000, and result in needlessly delaying the start of pregnancy. The HBA assay is easier to use, less expensive and more reliable than any other assay currently in use.