PGD不需用於非高齡病患

Day 3胚胎正常率約60%, Day 5胚胎正常率約80%
延長培養到第五天本身就是一種淘汰篩選過程
這可以解釋為何PGD/PGS不需用於非高齡病患

http://humrep.oxfordjournals.org/content/23/12/2818.full

Table II.

Pregnancy outcome after ART among women randomized to receive either standard care (active control group) or standard care with PGS (intervention group)^a

	Control group	PGS group	Between-group difference (95% confidence interval)b	Pvalue
Biochemical pregnancies (positive serum HCG) after ART	52	47
per randomized patient	52/120 (43.3%)	47/120 (39.2%)	−4.2% (−16.6 to 8.3)	0.52
per initiated cycle (treatment started)	52/107 (48.6%)	47/107 (43.9%)	−4.7% (−18.0 to 8.7)	0.49
per aspirated cycle	52/98 (53.1%)	47/100 (47.0%)	−6.2% (−20.0 to 7.8)	0.39
per embryo transfer cycle	52/89 (58.4%)	47/85 (55.3%)	−3.1% (−17.8 to 11.6)	0.68
Live birth deliveries after ART	37	37
per randomized patient	37/120 (30.8%)	37/120 (30.8%)	0.0% (−11.7 to 11.7)	1.00
per initiated cycle (treatment started)	37/107 (34.6%)	37/107 (34.6%)	0.0% (−12.7 to 12.7)	1.00
per aspirated cycle	37/98 (37.8%)	37/100 (37.0%)	−0.8% (−14.2 to 12.7)	0.91
per embryo transfer cycle	37/89 (41.6%)	37/85 (43.5%)	2.0% (−12.7 to 16.7)	0.79

• ^aStudy recruitment was terminated prematurely on the basis of futility at the first pre-specified interim analysis, after the enrolment of 120 of the projected 447 patients in each group. The data are presented as number of cases or percentages.
• ^bEarly stopping typically results in confidence intervals not as precise as originally intended.