Letrozole誘導排卵可下降排卵針之需求量

Letrozole合併FSH於誘導排卵可能可下降排卵針之需求劑量與費用
並不影響卵子之數目與懷孕率

http://humupd.oxfordjournals.org/content/14/6/571.full

Table III.

Comparison of patients (ovulatory infertility) treated with gonadotrophins and those treated with gonadotrophins plus letrozole in IVF treatment.

Data	Goswami et al. (2004)		Garcia-Velasco et al. (2005)		Schoolcraft et al. (2008)
	Letrozole + FSH	FSH	Letrozole + FSH	FSH	Letrozole + FSH	FSH
Cycles, no.	13	25	71	76	179	355
Days of stimulation	Not stated	Not stated	9.3 (0.3)	8.9 (0.2)	9.9 (1.3)	10.1 (1.6)
FSH dose, IU	150 (0)*	2865 (/228)*	3627 (116)	3804 (127)	4222 (742)	3937 (975)
Oocytes retrieved	1.6 (0.8)	2.1 (/0.7)	6.1 (0.4)	4.3 (0.3)	12 (6)	13 (5.3)
Estradiol on hCG day, pg/ml	227 (45)*	380 (46)*	770 (67)	813 (60)	1403 (965)**	3147 (1189)**
Pregnancy rate, %	23	24	22.4	15.2	Not stated	Not stated
Implantation rate, %	Not stated	Not stated	25**	9.4**	15	21
Ongoing pregnancy rate, %	Not stated	Not stated	Not stated	Not stated	37**	52**

• Data as mean (SD) unless otherwise stated.
• *P < 0.01 and **P < 0.05 between the groups of letrozole + FSH and FSH alone.