誘導排卵後期可施打hCG200iu/d取代rFSH

誘導排卵第8天以後可考慮施打hCG200iu/d, 取代rFSH
可降低rFSH劑量與花費並不影響懷孕率

http://humrep.oxfordjournals.org/content/24/11/2910.full

Table II

Cycle outcome measures*

	rFSH standard treatment group** mean (SD)	Low-dose hCG treatment group** mean (SD)	Between-group difference (95% CI)	P-value for between-group difference****
Total dose of rFSH, IU***	1617 (280)	1273 (260)	−344 (−483 to −205)	<0.001
Overall treatment duration, days	8.2 (1.6)	8.7 (1.6)	0.5 (−0.3 to 1.3)	0.19
RFSH duration, days	8.2 (1.6)	6.4 (1.3)	−1.8 (−2.6 to −1.1)	<0.001
hCG duration, days	0	2.3 (1.4)	2.3 (1.8–2.8)	<0.001
Number of COCs	12.3 (5.8)	11.1 (5.2)	−1.2 (−4.1 to 1.6)	0.40
Number of M II oocytes	10.1 (5.8)	8.9 (4.6)	−1.2 (−3.9 to 1.5)	0.38
Number of 2-PN oocytes	8.1 (5.0)	7.4 (4.0)	−0.7 (−3.1 to 1.6)	0.55

• COC, cumulus-oocyte complex; 2-PN, two pronuclei; M II, metaphase II.

Table III

Clinical outcome measures*

	rFSH standard treatment group* number of cases (percentage)	Low-dose hCG treatment group* number of cases (percentage)	Between-group difference (95% CI)	P-value for between-group difference
Number of patients with positive hCG	19	17
Per started cycle	19/35 (55%)	17/35 (49%)	5.7% (−16.9 to 27.5%)	0.81
Per retrieval	19/32 (59%)	17/29 (59%)	0.8% (−22.6 to 24.2%)	0.84
Per embryo transfer	19/29 (66%)	17/27 (63%)	2.6% (−21.3 to 26.3%)	0.94
Outcome for patients with positive hCG test
Biochemical pregnancy	5/19 (26%)	1/17 (6%)	−20.4% (−43.3 to 5.2%)	0.40
Miscarriage	3/19 (16%)	3/17 (18%)	2.0% (−22.7 to 27.4%)
Ectopic pregnancy	1/19 (5%)	0/17 (0%)	5.3% (−24.6 to 13.7%)
Ongoing pregnancy	2/19 (11%)	2/17 (12%)	1.2% (−21.3 to 25.1%)
Live birth	8/19 (42%)	11/17 (65%)	22.6% (−9.3 to 48.7%)
Number of ongoing pregnancies and live births
Per started cycle	10/35 (29%)	13/35 (37%)	8.6% (−13.0 to 29.1%)	0.45
Per retrieval	10/32 (31%)	13/29 (45%)	13.6% (−10.3 to 35.7%)	0.28
Per embryo transfer	10/29 (35%)	13/27 (48%)	13.7% (−11.5 to 36.7%)	0.30

• *Data are presented as number of cases including nominator and denominator values (percentages between brackets). All calculations have been carried out to full arithmetic precision, but results are shown as rounded values. Absolute between-group difference = (Low-dose hCG group value [third column]) − (rFSH group value [second column]). A negative value in the fourth column favours Low-dose hCG.