悅己有效改善PCO男性化

Pill Yasmin悅己 (30 microg ethinyloestradiol and 3 mg drospirenone)
服用6month可有效改善PCO男性化

http://www.ncbi.nlm.nih.gov/pubmed/17455042

Efficacy of an oral contraceptive containing drospirenone in the treatment of women with polycystic ovary syndrome.

Pehlivanov B, Mitkov M.

Author information

• Department of Obstetrics and Gynaecology, Medical University, Plovdiv, Bulgaria. blago_pehlivanov@yahoo.com

Abstract

OBJECTIVE:

To investigate the efficacy of a combined oral contraceptive containing 30 microg ethinyloestradiol and 3 mg drospirenone in the treatment of hyperandrogenism affecting women with the polycystic ovary syndrome (PCOS).

METHODS:

Prospective open study of 20 women for six cycles. At the beginning and at the end of the study the following values were determined: the Ferriman-Gallwey (F-G) score, body mass index, waist/hip ratio, serum levels of testosterone, SHBG, immune reactive insulin (IRI), glucose, the free androgenic index, and insulin resistance (HOMA-IR).

RESULTS:

All 20 women completed six cycles of therapy. The medication was well tolerated. At the end of the study there was a significant improvement of hirsutism, expressed in the decrease of the F-G score, accompanied by a decrease of testosterone and an increase of SHBG values. The carbohydrate metabolism was not affected significantly.

CONCLUSION:

The combined oral contraceptive containing 30 microg ethinyloestradiol and 3 mg drospirenone is an effective drug in the treatment of hyperandrogenism in women with PCOS; it elicits few side effects and does not significantly influence insulin resistance.