clomid使用於誘導排卵會造成子宮內膜延後黃體化1-2天&子宮內膜變差
reduction of pinopod formation in the mid-luteal phase (Creus et al., 2003).
The glandular density is reduced
http://humupd.oxfordjournals.org/content/12/5/617.full
Clomiphene protocols
Negative effects of clomiphene stimulation on the endometrium have been described in IVF cycles and in ovulation induction cycles since the 1980s (Garcia et al., 1984; Sterzik et al., 1988; Rogers et al., 1991). In clomiphene citrate/HMG cycles, endometrial histology was still in the proliferative state a few days after oocyte collection (Abate et al., 1987). The endometrial anti-estrogenic properties of clomiphene citrate have been used as an explanation for low pregnancy rates after clomiphene citrate despite high ovulation rates. Classical clomiphene stimulation leads to a delayed histological dating (Palomino et al., 2005) and might lead to a reduction of pinopod formation in the mid-luteal phase (Creus et al., 2003). The glandular density is reduced and the number of vacuolated cells increases (Sereepapong et al., 2000).
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