延後2天取卵可取較多卵子

傳統取卵時機為達3顆卵子>1.7cm
若不考慮內膜老化因素(轉為冷凍胚胎保存), 延後2天取卵可取較多卵子,

http://humrep.oxfordjournals.org/content/20/9/2453.full

http://www.ncbi.nlm.nih.gov/pubmed/15236997?dopt=Abstract

Table I.

Patient characteristics, stimulation data and hormonal values in donors randomized to the early-hCG or the late-hCG group the

	Early-hCG group (n=5)	Late-hCG group (n=5)	P
Age (years)	28.8 (6)	33.8 (7)	0.10
Body mass index (kg/m2)	26.3 (2.0)	26.7 (7.3)	0.50
Hormonal levels at initiation of stimulation
Estradiol (pg/ml)	40.0 (30.3)	30.0 (20.4)	0.29
Progesterone (ng/ml)	0.7 (0.4)	0.5 (0.4)	0.10
FSH (IU/l )	8.5 (5.0)	6.7 (4.0)	0.14
LH (IU/l)	2.9 (4.9)	2.4 (1.5)	0.17
Days of stimulation	7 (2)	9 (5)	0.03
Follicles on day of hCG
≥11 mm	10 (8.0)	16 (23.0)	0.06
≥15 mm	5 (9.0)	11 (19.0)	0.04
≥17 mm	4.0 (2.5)	7.0 (9.0)	0.04
Hormonal levels on day of hCG
Estradiol (pg/ml)	900 (1351)	1400 (2571)	0.15
Progesterone (ng/ml)	1.2 (0.95)	1.4 (0.8)	0.69
FSH (IU/l)	10.5 (7)	11.8 (6)	0.31
LH (IU/l)	0.9 (2.4)	0.7 (0.4)	0.84
Hormonal levels on day of hCG +1
Estradiol (pg/ml)	1251 (2291)	2395 (2414)	0.79
Progesterone (ng/ml)	4.8 (4)	9.1 (3)	0.02
Cumulus–oocyte complexes retrieved	6.0 (8.0)	16.0 (8.0)	0.12

• Values are expressed as median (interquartile range).

Fertil Steril. 2004 Jul;82(1):102-7.

Prolongation of the follicular phase in in vitro fertilization results in a lower ongoing pregnancy rate in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists.

Kolibianakis EM1, Albano C, Camus M, Tournaye H, Van Steirteghem AC, Devroey P.

Author information

Abstract

OBJECTIVE:

To assess the effect of altering the timing of hCG administration on ongoing pregnancy rates in patients stimulated with recombinant FSH (rec-FSH) and GnRH antagonists for IVF.

DESIGN:

Prospective, randomized, controlled trial.

SETTING:

Tertiary referral center.

PATIENT(S):

Four hundred thirteen patients undergoing IVF.

INTERVENTION(S):

Rec-FSH stimulation starting on day 2 of the cycle combined with daily GnRH antagonist starting on day 6 of stimulation. Patients were randomized to receive 10000 IU of hCG either as soon as at least three follicles were >or=17 mm on ultrasound (early-hCG group, 208 patients) or 2 days later after this criterion was met (late-hCG group, 205 patients).

MAIN OUTCOME MEASURE(S):

Ongoing pregnancy rate.

RESULT(S):

Fertilization rates and number and quality of embryos transferred did not differ between the two groups. However, a significantly lower ongoing pregnancy rate was present in the late-hCG as compared with the early-hCG group (25.0% vs. 35.6%, respectively).

CONCLUSION(S):

Prolongation of the follicular phase in patients stimulated with rec-FSH and GnRH antagonists for IVF does not affect oocyte or embryo quality but is associated with a significantly lower ongoing pregnancy rate.