decapetetyl 0.2-0.4mg 均可用於誘導排卵

GnRHa (decapetetyl triptorelin) 0.2-0.4mg (2-4支)均可用於誘導排卵

卵數量, 胚胎數量, 胚胎品質並無差異

LH, P4, 數值, 0.4mg>0.3, 0.2mg

Fertil Steril. 2015 Oct 31. pii: S0015-0282(15)02021-X. doi: 10.1016/j.fertnstert.2015.10.014. [Epub ahead of print]

Gonadotropin-releasing hormone agonist trigger in oocyte donors co-treated with a gonadotropin-releasing hormone antagonist: a dose-finding study.

Ngoc Lan Vuong T1, Tuong Ho M2, Duc Ha T3, Tuan Phung H4, Bao Huynh G4, Humaidan P5.

Author information

Abstract

OBJECTIVE:

To determine the optimal GnRH agonist dose for triggering of oocyte maturation in oocyte donors.

DESIGN:

Single-center, randomized, parallel, investigator-blinded trial.

SETTING:

IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam.

PATIENT(S):

One hundred sixty-five oocyte donors (aged 18-35 years, body mass index [BMI] <28 kg/m2, antimüllerian hormone level >1.25 ng/mL, and antral follicle count ≥6).

INTERVENTION(S):

Ovulation trigger with 0.2, 0.3, or 0.4 mg triptorelin in a GnRH antagonist cycle.

MAIN OUTCOME MEASURE(S):

The primary end point was number of metaphase II oocytes. Secondary end points were fertilization and cleavage rates, number of embryos and top-quality embryos, steroid levels, ovarian volume, and ongoing pregnancy rate (PR) in recipients.

RESULT(S):

There were no significant differences between the triptorelin 0.2, 0.3, and 0.4 mg trigger groups with respect to number of metaphase II oocytes (16.0 ± 8.5, 15.9 ± 7.8, and 14.7 ± 8.4, respectively), embryos (13.2 ± 7.8, 11.7 ± 6.9, 11.8 ± 7.0), and number of top-quality embryos (3.8 ± 2.9, 3.6 ± 3.0, 4.1 ± 3.0). Luteinizing hormone levels at 24 hours and 36 hours after trigger was significantly higher with triptorelin 0.4 mg versus 0.2 mg and 0.3 mg (9.8 ± 7.1 IU/L vs. 7.3 ± 4.1 IU/L and 7.2 ± 3.7 IU/L, respectively; 4.6 ± 3.2 IU/L vs. 3.2 ± 2.3 IU/L and 3.3 ± 2.1 IU/L, respectively. Progesterone level at oocyte pick-up +6 days was significantly higher in the 0.4-mg group (2.2 ± 3.7 ng/ml) versus 0.2 mg (1.1 ± 1.0 ng/ml) and 0.3 mg (1.2 ± 1.6 ng/ml). One patient developed early-onset severe ovarian hyperstimulation syndrome (OHSS).

CONCLUSION(S):

No significant differences between triptorelin doses of 0.2, 0.3, and 0.4 mg used for ovulation trigger in oocyte donors were seen with regard to the number of mature oocytes and top-quality embryos.