本篇質疑於破卵日當天測P4之必要性
P4數值與懷孕率無明顯關聯

P4值與E2值, 卵數量呈現正相關

Fertil Steril. 2015 Oct 9. pii: S0015-0282(15)01925-1. doi: 10.1016/j.fertnstert.2015.09.008. [Epub ahead of print]

Should progesterone on the human chorionic gonadotropin day still be measured?

Martinez F1, Rodriguez I2, Devesa M2, Buxaderas R2, Gómez MJ2, Coroleu B2.

Author information

Abstract

OBJECTIVE:

To evaluate in our setting whether there is currently a level of P on the hCG day (P-hCG) predictive of no pregnancy.

DESIGN:

Observational study of prospectively collected data of the P-hCG levels of stimulated IVF cycles.

SETTING:

In vitro fertilization unit.

PATIENT(S):

All cycles of IVF/intracytoplasmic sperm injection with fresh embryo transfer performed between January 2009 and March 2014.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Pregnancy rate.

RESULT(S):

Clinical pregnancy rate per ET was 38.7% and live birth rate was 29.1%. The P-hCG concentration was positively correlated to E2 on the hCG day, and the number of oocytes was negatively correlated to age. Progesterone on hCG day was higher among agonist- compared with antagonist-treated patients (mean ± SD: 1.13 ± 0.69 ng/mL vs. 0.97 ± 0.50 ng/mL) and among recombinant FSH compared with recombinant FSH + hMG stimulation (mean ± SD: 1.11 ± 0.58 ng/mL vs. 0.94 ± 0.50 ng/mL). Pregnancy rate was positively associated with the number of oocytes. There was no correlation between P-hCG value and pregnancy rate, overall or according to the type of treatment.

CONCLUSION(S):

In our setting there is no P-hCG value differentiating a good from a poor cycle success rate.