不孕症常合併生殖道(子宮頸內)金黃色葡糖球菌之高感染率

Int J Fertil Steril. 2017 Apr-Jun;11(1):28-32. Epub 2016 Nov 11.

The Frequency of Staphylococcus aureus Isolated from Endocervix of Infertile Women in Northwest Iran.

Akhi MT1, Esmailkhani A2, Sadeghi J2, Niknafs B3, Farzadi L4, Akhi A5, Nasab EN2.

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Abstract

BACKGROUND:

Infertility is one of the major social issues. Due to the asymptomatic cervical infection associated with Staphylococcus aureus (S. aureus), the majority of patients remain undiagnosed. The present study intended to assess the frequency of S. aureus isolated from infertile women's endocervix in northwest Iran.

MATERIALS AND METHODS:

In a descriptive cross sectional study, specimens were randomly collected during vagina examination using a sterile speculum and swabbing. After performance of antibiotic susceptibility testing, polymerase chain reaction (PCR) was used to identify methicillin-resistance S. aureus (MRSA) and toxic shock syndrome toxin-1 (TSST-1).

RESULTS:

About 26 (26%) and 9 (9%) women's urogenital tracts were colonized by S. aureus and Candida spp., respectively, of which three (11.5%) patients were infected with fungi and S. aureus, simultaneously. Antibiotic susceptibility results showed high activity of vancomycin and co-trimoxazole on isolates. Regarding PCR results, mecA sequences were detected in 7 (26.9%) strains, whilst the tst gene encoding TSST-1 was not detected in any of clinical strains.

CONCLUSION:

The prevalence of S. aureus was very high in infertile women. Therefore, it demands all patients undergoing infertility treatment to be investigated thoroughly for this type of infection.