大劑量(3#/d)&長療程(M2-11)排卵藥clomid 可提高抗clomid PCO排卵率

J Gynecol Obstet Hum Reprod. 2017 May 24. pii: S2468-7847(17)30139-3. doi: 10.1016/j.jogoh.2017.05.007. [Epub ahead of print]

Long-term use of clomiphene citrate in induction of ovulation in PCO patients with clomiphene citrate resistance.

Elkhateeb RR1, Mahran AE2, Kamel HH2.

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Abstract

OBJECTIVE:

The aim of our study to evaluate the effect of extended clomiphene citrate treatment on the ovulation rate, pregnancy rate, and hormonal profile of clomiphene resistant PCOS.

METHODOLOGY:

This a prospective study conducted in Maternity Hospital Minia University, 200 patients with PCOS recruited in the study during the period from September 2015 till February 2016 (6 months was duration of the study), they were diagnosed as PCO with clomiphene resistance before being recruited in the study. They received 150mg clomiphene citrate for 10 days start in 2nd day of cycle for three consecutive cycles, and followed up for another three months without treatment, last follow-up cycle was on February. We studied the effect of extended treatment with CC in ovulation rate, pregnancy rate and hormonal profile in patients before and after treatment.

RESULTS:

There was significant improvement in ovulation rate in the patients after extended CC treatment for 3 months and 3 months follow-up (as 12 cases in the first cycle and 32 cases in the second cycle and increased to 76 cases in the third cycle) while no ovulation documented before treatment pregnancy rate was 17% itis generally low but it highly significant when compared with was zero preceding treatment.

CONCLUSION:

Extended CC treatment is good method to improve ovulation and pregnancy rate in CC resistant PCOS but further multi-center studies are needed to provide more powerful evidence.