最佳受孕受孕狀況為取得10-15顆卵  受孕形成9顆胚胎
低於9顆胚胎 或高於9顆胚胎均會下降懷孕率

Fertil Steril. 2019 Jun 18. pii: S0015-0282(19)30401-7. doi: 10.1016/j.fertnstert.2019.04.023. [Epub ahead of print]

Clinical pregnancy (CP) and live birth (LB) increase significantly with each additional fertilized oocyte up to nine, and CP and LB decline after that: an analysis of 15,803 first fresh in vitro fertilization cycles from the Society for Assisted Reproductive Technology registry.

Smeltzer S1, Acharya K1, Truong T2, Pieper C2, Muasher S3.

Author information

Abstract

OBJECTIVE:

To study the association between the total number of fertilized oocytes available and pregnancy outcomes in first fresh IVF cycles with a single blastocyst transfer.

DESIGN:

Retrospective cohort study.

SETTING:

Not applicable.

PATIENT(S):

A total of 15,803 patients from SART reporting fertility clinics.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Primary outcomes were clinical pregnancy (CP), live birth (LB), and miscarriage rates. Logistic regression was used to investigate the association between the number of fertilized eggs and each outcome.

RESULT(S):

The median number of total oocytes was 15, and the median number of fertilized oocytes was nine. The odds of a clinical pregnancy were 8% higher for each additional fertilized oocyte up to nine (odds ratio [OR] 1.08; 95% confidence interval [CI] 1.07-1.10) and declined by 9% for every additional fertilized oocyte after nine (OR 0.91; 95% CI 0.89-0.94). Similarly, the odds of an LB was 8% higher for every additional fertilized oocyte up to none (OR 1.08; 95% CI 1.06-1.10) and declined by 8% for every additional fertilized oocyte over nine (OR 0.92; 95% CI 0.90-0.94).

CONCLUSION(S):

Odds of pregnancy outcomes (CP, LB) increase significantly with every additional fertilized oocyte up to nine, and CP and LB decline after that in first fresh autologous cycles with a single blastocyst transfer.