低於10ml 可發生卵巢功能下降, AMH下降 , FSH 上升
Fertil Steril. 2020 Feb;113(2):453-459. doi: 10.1016/j.fertnstert.2019.09.029.
The precise ovarian volume is significantly associated with serum concentrations of antimüllerian hormone, the luteinizing hormone/follicle-stimulating hormone ratio, and total testosterone.
Wakimoto Y1, Pors SE2, Cadenas J2, Colmorn L3, Ernst E4, Dueholm M5, Fedder J6, Mamsen LS2, Kristensen SG2, Andersen CY7.
Abstract
OBJECTIVE:
To evaluate potential associations between concentrations of antimüllerian hormone (AMH) and T as well as the LH/FSH ratio and the unbiased precise ovarian volume obtained after unilateral ovariectomy.
DESIGN:
Cohort study.
SETTING:
University hospital.
PATIENT(S):
A total of 765 patients having one ovary surgically removed for fertility preservation. Inclusion criteria were age >15 years and ovarian volume <25 mL; 386 women had one or more hormone parameter (AMH, LH, FSH, or total T) determined before oophorectomy.
INTERVENTION(S):
None.
MAIN OUTCOME MEASURE(S):
A precise weight of the ovary was equated with ovarian volume. Associations between ovarian volume and AMH, the LH/FSH ratio, T concentrations, and body mass index (BMI) were evaluated. Patient characteristics in relation to ovarian volume cutoff values between 8 and 12 mL were also examined.
RESULT(S):
Ovarian volume was significantly positively associated with concentrations of AMH, the LH/FSH ratio, and T. Ovarian volume, concentrations of AMH and LH, and the LH/FSH ratio were significantly augmented in women having ovarian volumes above a threshold of 8, 9, and 10 mL compared with those below. Average age, FSH, and T concentrations did not differ between below and above the 10 mL threshold. There was a significant association between BMI and ovarian volume and BMI and T, while other hormone parameters were nonsignificant.
CONCLUSION(S):
The precise ovarian volume reflected ovarian activity measured as circulating concentrations of AMH and T as well as the LH/FSH ratio. These significant associations showed continuous progression, and a 10 mL threshold offered no clear difference compared with other volume threshold values.
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