一旦植入管合併細菌感染，懷孕率為%
J Gynecol Obstet Hum Reprod. 2020 Mar 12:101727. doi: 10.1016/j.jogoh.2020.101727. [Epub ahead of print]
Does bacterial colonization during embryo transfer have an impact on pregnancy rate in ICSI? : Tunisian preliminary results.
Abstract
INTRODUCTION:
Embryos' transfer into the uterine cavity remains a limiting factor in the success of intracytoplasmic sperm injection (ICSI). This study aimed to evaluate the impact of cervico-vaginal colonization on ICSI outcomes.
MATERIEL AND METHODS:
Longitudinal, prospective and analytical study, conducted from February 1 st to October 31 st, 2017. On the day of embryos' transfer, patients with the following criteria were included: Age ≤ 40, normal uterine ultrasound and hysteroscopy, first or second attempt of ICSI, use of fresh semen and transfer of at least one good quality embryo. Three samples were done for microbiological analysis: vaginal secretions, cervical mucus and the tip of the transfer catheter.
RESULTS:
The study included 40 patients. Pregnancy rate was 52.5%. Catheter contamination occurred in nine cases (22.5%). The most frequently isolated bacteria were Streptococcus anginosus (37% of cases), Gardnerella vaginalis (27% of cases) and Streptococcus agalactiae (18% of cases). In all cases of contamination, the same bacteria were found also in the vagina and cervical mucus. In cases of contamination with Gardnerella vaginalis, the study of vaginal flora showed bacterial vaginosis. No pregnancy was obtained when contamination of the transfer catheter occurred. In the absence of contamination, pregnancy rate was 61.2% (ρ = 0.003). Both populations (patients with catheter contamination and patients without catheter contamination) were comparable regarding epidemiological characteristics and ICSI attempt data.
CONCLUSION:
Contamination of the transfer catheter by cervical-vaginal bacteria appears to affect IVF results. Systematic antibiotic prophylaxis could be proposed to reduce this negative impact.
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