Fertil Steril. 2020 Mar 5. pii: S0015-0282(19)32620-2. doi: 10.1016/j.fertnstert.2019.12.018. [Epub ahead of print]
Ultralong administration of gonadotropin-releasing hormone agonists before in vitro fertilization improves fertilization rate but not clinical pregnancy rate in women with mild endometriosis: a prospective, randomized, controlled trial.
Kaponis A1, Chatzopoulos G2, Paschopoulos M2, Georgiou I2, Paraskevaidis V2, Zikopoulos K2, Tsiveriotis K3, Taniguchi F4, Adonakis G3, Harada T4.
Abstract
OBJECTIVE:
To evaluate the effects of gonadotropin-releasing hormone agonists (GnRH-a) on fertility in women with mild endometriosis who are undergoing in vitro fertilization and embryo transfer (IVF-ET) procedures.
DESIGN:
Prospective, randomized, controlled trial.
SETTING:
Three tertiary university hospitals.
PATIENT(S):
Four hundred infertile women with mild endometriosis, documented with laparoscopy, undergoing IVF and 200 women with tubal factor infertility.
INTERVENTION(S):
Administration of GnRH-a for 3 months before an IVF attempt (group A, n = 200) or IVF without GnRH-a (group B, n = 200).
MAIN OUTCOME MEASURE(S):
Follicular fluid (FF) levels of tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-8, and IL-1 receptor antagonist; fertilization rate (FR), implantation rate (IR), quality of embryos, and clinical pregnancy rate (PR).
RESULT(S):
Women who received GnRH-a had a statistically significantly reduced concentration of FF cytokines compared with women who did not receive this regimen. Women in group B had a reduced FR (61.7; 95% CI, 59.20-64.20) compared with the women in group A (72.7; 95% CI, 70.50-74.90) and compared with the women with tubal factor infertility (74.7; 95% CI, 72.00-77.24). The embryo quality, IR, and clinical PR showed no statistically significant improvement in the women of group A compared with group B.
CONCLUSION(S):
Women who received GnRH-a for 3 months had a lower concentration of FF cytokines. These women had also a higher FR than the women who did not receive GnRH-a. However, the IR, embryo quality, and clinical PR showed no statistically significant difference when comparing the two groups. CLINICALTRIALS.
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