2011年11月27日

玻璃化冷凍法應用於血球細胞之保存

玻璃化冷凍法可應用於血球細胞之保存
應用微滴噴灑技術可以玻璃化冷凍法有效保存血球細胞
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055869/?tool=pubmed

PLoS One. 2011 Mar 11;6(3):e17530.

Blood banking in living droplets.

Samot J, Moon S, Shao L, Zhang X, Xu F, Song Y, Keles HO, Matloff L, Markel J, Demirci U.

Source

Demirci Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.

Abstract

Blood banking has a broad public health impact influencing millions of lives daily. It could potentially benefit from emerging biopreservation technologies. However, although vitrification has shown advantages over traditional cryopreservation techniques, it has not been incorporated into transfusion medicine mainly due to throughput challenges. Here, we present a scalable method that can vitrify red blood cells in microdroplets. This approach enables the vitrification of large volumes of blood in a short amount of time, and makes it a viable and scalable biotechnology tool for blood cryopreservation.

PMID:: 21412411; [PubMed - indexed for MEDLINE]
PMCID: PMC3055869

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