胚胎玻璃化冷凍解凍植入之懷孕率比 新鮮胚胎植入之懷孕率還高

本篇指出，將所有第3天胚胎玻璃化冷凍後於往後週期再解凍植入之懷孕率(53%)比不冷凍直接將第3天新鮮胚胎植入之懷孕率(33%)還高。
冷凍解凍胚胎存活率為98%。
新鮮週期之高E2值可能抑制LH及子宮內膜之接受度。

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Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Jul;35(7):673-8.

Vitrification technology in whole embryo freezing.

Xie X, Zou L, Shen Y, Xiong F, Chen J.

Source

Maternal and Child Health Care Hospital, Nanjing Medical University, Wuxi Jiangsu 214002, China. xxd3100@163.com

Abstract

OBJECTIVE:

To investigate the clinical outcome of patients who underwent whole embryo vitrification freezing and thawed frozen embryo transplantation, and to compare it with the patients at the same period in the fresh cycle to explore the value of vitrification technology in the whole embryo freezing combined with recovery transplantation.

METHODS:

The whole embryo freezing group included 40 untransplanted cases of in-vitro fertilization (IVF), while another 300 patients in the fresh cycle with in vitro fertilization and embryo transfer (IVF-ET) at the same period served as the fresh cycle group. The average number of transferred embryos, high-quality embryos, endometrial thickness, estradiol (E₂) level, and clinical pregnancy rate were compared.

RESULTS:

The average number of transferred embryos, high-quality embryos, difference in endometrial thickness were not significant between the 2 groups (P>0.05); the E₂ level of the fresh cylcle group was significantly higher than that of the whole embryo freezing group (P<0.05), and the clinical pregnancy rate in the fresh cylcle group was significantly lower than that of the whole embryo freezing group (P<0.05).

CONCLUSION:

Vitrification technology is a simple, reliable, and efficient embryo freezing technology. For patients who meet the requirements, whole embryo vitrfication freezing and thawed frozen embryo transplantation is feasible. It is worth for further clinical research.