早晚打排卵針與集中於早上打排卵針臨床效果類似

IVF於早晚打排卵針與集中於早上打排卵針臨床效果類似

http://www.ncbi.nlm.nih.gov/pubmed?term=Decreased%20gonadotropin%2C%20Abdo%20G

J Assist Reprod Genet. 2012 Apr;29(4):321-4. Epub 2012 Jan 25.

Decreased gonadotropin requirements in once daily compared to twice daily administration: a prospective, randomized study.

Sharara FI, Collins MG, Abdo G.

Source

Virginia Center for Reproductive Medicine, Reston, VA 20190, USA. fsharara@aol.com

Abstract

OBJECTIVE:

Despite the lack of any scientific data, many ART programs split the daily gonadotropin dose during ovarian stimulation, while others give the entire dose during a single administration, usually at night.

DESIGN:

Prospective randomized.

PATIENT(S):

213 women undergoing IVF/ICSI cycles at a single private ART center.

INTERVENTION(S):

Gonadotropin administration once daily compared to twice daily.

MAIN OUTCOME MEASURE(S):

Gonadotropin usage, clinical and ongoing PR RESULTS: There were 110 women in the once daily compared to 103 in the twice daily arm. All cycles were blastocyst transfers. There was a significantly lower FSH use in the once daily arm compared to the twice daily arm (1507.5 ± 517.5 IU vs. 1702.5 ± 622.5, P = 0.015), and a trend towards lower hMG use in the once daily arm (1342.5 ± 562.5 IU vs. 1462.5 ± 645.0, P = 0.15), without compromising clinical pregnancy rate (PR) (71.8% vs. 70.9%, P = NS) or delivery/ongoing PR (58.2% vs. 62.1%, P = NS). There were no differences in age, body mass index (BMI), peak estradiol, peak progesterone, retrieved oocytes, fertilized oocytes, number of ET, or PR.

CONCLUSIONS:

Once daily administration is associated with lower gonadotropin usage without compromising success rates.