黃體化牽涉複雜的賀爾蒙, 分子訊號及血管形成交互作用

黃體Corpus luteum主要由granulosa cell & thecal cell組成
黃體化luteinization 牽涉複雜的賀爾蒙，分子訊號及血管形成angiogenesis交互作用interaction

http://www.biolreprod.org/content/63/1/2.full

Models of Luteinization1

1. Centre de recherche en reproduction animale, Faculté de médecine vétérinaire, Université de Montréal, St-Hyacinthe, Québec, Canada J2S 7C6

 

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Abstract

Luteinization is essential to the success of early gestation. It is the process by which elements of the ovarian follicle, usually including both theca interna and granulosa cells, are provoked by the ovulatory stimulus to develop into the corpus luteum. Although there are significant species differences in luteinization, some elements pervade, including the morphological and functional differentiation to produce and secrete progesterone. There is evidence that luteinization results in granulosa cell exit from the cell cycle. The mechanisms that appear to control luteinization include intracellular signalling pathways, cell adhesion factors, intracellular cholesterol and oxysterols, and perhaps progesterone itself as a paracrine or intracrine regulator. Cell models of luteinization, along with some of the conflicting observations on the luteinization process, are discussed in this review.