冷凍胚胎高於新鮮胚胎植入懷孕率

冷凍胚胎植入懷孕率39%高於新鮮胚胎植入懷孕率28%

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922708/#!po=2.63158

RETRACTED ARTICLE: Can fresh embryo transfers be replaced by cryopreserved-thawed embryo transfers in assisted reproductive cycles? A randomized controlled trial

Abbas Aflatoonian, Homa Oskouian, [...], and Leila Oskouian

Additional article information

Abstract

Purpose

Controlled ovarian hyperstimulation has been shown to advance endometrial maturation and adversely affects implantation in ART. It has been reported that there is a better embryo-endometrium synchrony in frozen-thawed embryo transfer cycles than fresh embryo transfer cycles. The objective of this study was to compare ongoing pregnancy rates between fresh ET and FET cycles.

Methods

In an open prospective, controlled study, the patients who were classified as high responders, were randomized to either fresh ET or FET. The embryos in FET group were cryopreserved with vitrification by Cryotop method.

Results

A total of 374 patients were included, 187 of which were randomized to FET and 187 to fresh ET. There were 39% (n=73) ongoing pregnancy in FET group compared with 27.8% (n=52) in fresh ET group[odds ratio = 1.66;95% confidence interval = 1.07–2.56; p=0.02].

Conclusions

FETs can be performed instead of fresh ETs to improve the outcome of ART in highly selected patients.

Keywords: Endometrial receptivity, Fresh embryo transfer, Frozen-thawed embryo transfer, Ongoing pregnancy, Vitrification