DHEA可提高卵巢反應

DHEA 對於高齡，卵巢功能不佳病患，可提高卵巢反應，卵泡生成

http://www.ncbi.nlm.nih.gov/pubmed/23737215

J Assist Reprod Genet. 2013 Sep;30(9):1239-44. doi: 10.1007/s10815-013-0018-x. Epub 2013 Jun 5.

Is there a role for DHEA supplementation in women with diminished ovarian reserve?

Fouany MR, Sharara FI.

Author information

• Department of Obstetrics and Gynecology, Charles Cole Memorial Hospital, Coudersport, PA, USA.

Abstract

PURPOSE:

Poor ovarian reserve and poor ovarian response presents a challenge to IVF centers. Dehydroepiandrosterone (DHEA) supplementation is increasingly being used by many IVF centers around the world in poor responders despite the lack of convincing data. We therefore examined the rationale for the use of DHEA in poor responders, address the relevant studies, present new data, and address its potential mechanisms of action.

METHODS:

All published articles on the role of DHEA in infertile women from 1990 to April 2013 were reviewed.

RESULTS:

Several studies have suggested an improvement in pregnancy rates with the use of DHEA. Potential mechanisms include improved follicular steroidogenesis, increased IGF-1, acting as a pre-hormone for follicular testosterone, reducing aneuploidy, and increasing AMH and antral follicle count. While the role of DHEA is intriguing, evidence-based recommendations are lacking.

CONCLUSIONS:

While nearly 25 % of IVF programs use DHEA currently, large randomized prospective trials are sorely needed. Until (and if) such trials are conducted, DHEA may be of benefit in suitable, well informed, and consented women with diminished ovarian reserve.