Aspirin可能會提高懷孕早期絨毛膜下血腫之機率

Fertil Steril. 2016 Jan 25. pii: S0015-0282(16)00044-3. doi: 10.1016/j.fertnstert.2016.01.009. [Epub ahead of print]

Subchorionic hematomas are increased in early pregnancy in women taking low-dose aspirin.

Truong A1, Sayago MM2, Kutteh WH3, Ke RW4.

Author information

Abstract

OBJECTIVE:

To determine the frequency of subchorionic hematomas (SCH) in first-trimester ultrasound examinations of patients with infertility and recurrent pregnancy loss (RPL) and in patients from a general obstetric population. To determine if the method of assisted reproduction utilized or the use of anticoagulants, such as heparin and aspirin (ASA), influenced frequency of SCH.

DESIGN:

Prospective, cohort study.

SETTING:

Fertility clinic and general obstetrics clinic.

PATIENT(S):

Five hundred and thirty-three women who were pregnant in the first-trimester.

INTERVENTIONS:

Not applicable.

MAIN OUTCOME MEASURE(S):

Frequencies of subchorionic hematomas in women based on diagnosis, use of anticoagulants, and fertility treatment.

RESULT(S):

SCH were identified in 129/321 (40.2%) in the study group compared to 23/212 (10.9%) in the control group. Fertility diagnosis and the use of heparin did not appear to affect the frequency of SCH in the first trimester; however, SCH occurred at an almost four-fold increase in patients taking ASA compared to those not taking ASA, regardless of fertility diagnosis or method of fertility treatment.

CONCLUSION(S):

The use of ASA may be associated with an increased risk of developing a SCH during the first trimester. The increased frequencies of SCH in pregnancies of patients attending a fertility clinic compared to women from a general obstetrical practice was highly correlated with the use of ASA.