BRCA陽性病患施行試管並不會增加卵巢癌風險

Fertil Steril. 2015 Dec 14. pii: S0015-0282(15)02118-4. doi: 10.1016/j.fertnstert.2015.11.034. [Epub ahead of print]

Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation.

Gronwald J1, Glass K2, Rosen B3, Karlan B4, Tung N5, Neuhausen SL6, Moller P7, Ainsworth P8, Sun P9, Narod SA10, Lubinski J1, Kotsopoulos J9; Hereditary Breast Cancer Clinical Study Group.

Collaborators (68)

Author information

Abstract

OBJECTIVE:

To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation.

DESIGN:

A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer.

SETTING:

Genetic clinics.

PATIENT(S):

Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment.

RESULT(S):

There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18-2.33) and the subsequent risk of ovarian cancer.

CONCLUSION(S):

Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.