約15%精液內有HPV病毒
2%為高危險HPV病毒
但HPV病毒與精液品質無關

Hum Reprod. 2016 Feb;31(2):280-6. doi: 10.1093/humrep/dev317. Epub 2016 Jan 2.

Presence of human papillomavirus in semen in relation to semen quality.

Luttmer R1, Dijkstra MG2, Snijders PJ1, Hompes PG2, Pronk DT1, Hubeek I3, Berkhof J4, Heideman DA1, Meijer CJ5.

Author information

Abstract

STUDY QUESTION:

Is the presence of human papillomavirus (HPV) in semen associated with impairment of semen quality?

SUMMARY ANSWER:

In a large cohort of males seeking fertility evaluation, no associations were observed between seminal HPV presence and semen parameters.

WHAT IS KNOWN ALREADY:

HPV is commonly detected in semen samples. Whether the presence of HPV is related to impairment of semen quality, remains unclear.

STUDY DESIGN, SIZE, DURATION:

This cross-sectional study included a cohort of 430 males.

PARTICIPANTS/MATERIALS, SETTING, METHODS:

Male partners in couples seeking fertility evaluation provided one semen sample per person. Semen samples were tested for HPV-DNA using GP5+/6+-PCR. Sperm concentration was counted and motility was assessed in a Makler counting chamber at a magnification of ×200. The presence of antisperm antibodies was assessed by a mixed agglutination reaction (MAR)-test.

MAIN RESULTS AND THE ROLE OF CHANCE:

Overall HPV was detected in 14.9% (64/430) of semen samples, including 2.1% (9/430) that contained both high-risk (hr) HPV and low-risk (lr) HPV types, 8.8% (38/430) with exclusively hrHPV types and 4.0% (17/430) with exclusively lrHPV types. The presence of HPV in semen was not associated with the age of the participants, seminal pH, semen volume, total sperm count, sperm concentration, progressive motility or the presence of antisperm antibodies.