多囊PCO病患若合併男性賀爾蒙過高或過度肥胖，
日後合併糖尿病高血脂機率更高

Fertil Steril. 2017 Jan 12. pii: S0015-0282(16)63089-3. doi: 10.1016/j.fertnstert.2016.12.017. [Epub ahead of print]

Normo- and hyperandrogenic women with polycystic ovary syndrome exhibit an adverse metabolic profile through life.

Pinola P1, Puukka K2, Piltonen TT1, Puurunen J1, Vanky E3, Sundström-Poromaa I4, Stener-Victorin E5, Lindén Hirschberg A6, Ravn P7, Skovsager Andersen M8, Glintborg D8, Mellembakken JR9, Ruokonen A2, Tapanainen JS10, Morin-Papunen LC11.

Author information

Abstract

OBJECTIVE:

To compare the metabolic profiles of normo- and hyperandrogenic women with polycystic ovary syndrome (PCOS) with those of control women at different ages during reproductive life.

DESIGN:

Case-control study.

SETTING:

Not applicable.

PATIENT(S):

In all, 1,550 women with normoandrogenic (n = 686) or hyperandrogenic (n = 842) PCOS and 447 control women were divided into three age groups: <30, 30-39, and >39 years).

INTERVENTIONS(S):

None.

MAIN OUTCOME MEASURE(S):

Body mass index (BMI), waist circumference, blood pressure, glucose, insulin, cholesterol, lipoproteins, triglycerides and high-sensitivity C-reactive protein.

RESULT(S):

Both normo- and hyperandrogenic women with PCOS were more obese, especially abdominally. They had increased serum levels of insulin (fasting and in oral glucose tolerance tests), triglycerides, low-density lipoprotein, and total cholesterol, higher blood pressure, and lower high-density lipoprotein levels independently from BMI compared with the control population as early as from young adulthood until menopause. The prevalence of metabolic syndrome was two- to fivefold higher in women with PCOS compared with control women, depending on age and phenotype, and the highest prevalence was observed in hyperandrogenic women with PCOS at late reproductive age.

CONCLUSION(S):

When evaluating metabolic risks in women with PCOS, androgenic status, especially abdominal obesity and age, should be taken into account, which would allow tailored management of the syndrome from early adulthood on.