試管嬰兒誘導排卵及取卵可能提高病患體內睪固酮濃度

1. 試管嬰兒誘導排卵及取卵可能提高病患體內睪固酮濃度
2. 睪固酮濃度與誘導排卵呈正相關
3. 睪固酮濃度與取卵數目呈正相關
4. 睪固酮濃度並不會對懷孕結果產生明顯不良影響

Fertil Steril. 2011 Nov 22. [Epub ahead of print]

Early pregnancy testosterone after ovarian stimulation and pregnancy outcome.

Gustin SL, Mukherjee G, Baker VL, Westphal LM, Milki AA, Lathi RB.

Source

Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California.

Abstract

OBJECTIVE:

To examine early pregnancy (EP) testosterone (T) after ovarian stimulation and its effect on singleton pregnancy outcomes.

DESIGN:

Prospective cohort study.

SETTING:

University-based tertiary care center.

PATIENT(S):

Subfertile women who conceived with or without fertility treatment.

INTERVENTION(S):

Ovarian stimulation for assisted reproduction, collection of serum total T levels in early pregnancy, and pregnancy follow-up.

MAIN OUTCOME MEASURE(S):

Rate of preterm delivery, low birth weight (LBW) (<2,500 g), and hypertensive disorders of pregnancy.

RESULT(S):

EP serum samples were measured from 266 singleton pregnancies. The mean T level among spontaneous conceptions was 74.90 ng/dL (SD 48.35 ng/dL); 103 ng/mL was the 90th percentile. Mean EP T was increased among patients who underwent ovarian stimulation compared with nonstimulated control subjects. In patients undergoing IVF, T levels in EP were linearly correlated with the number of oocytes retrieved. When pregnancy outcomes in women with normal T were compared with women with elevated T (>90th percentile), we did not see an increased risk for preterm delivery, hypertensive disorders of pregnancy, LBW infants, or cesarean delivery (odds ratio ratios 1.43, 0.38, 1.39, and 0.85, respectively).

CONCLUSION(S):

Elevations in EP T are associated with ovarian stimulation but do not appear to be associated with adverse pregnancy outcome. Further investigation to determine the etiology of increased maternal and neonatal morbidity among subfertile women is warranted.