服用metformin (glucophage)可減少卵巢過度刺激

1. 服用metformin (glucophage)(500 mg three times daily)可減少卵巢過度刺激
2. 服用metformin可能增加排卵藥的使用劑量及誘導排卵的時間
3. 服用metformin可能減少E(2)的數值
4. 此意味著服用metformin可能減少卵泡的取出量

Fertil Steril. 2011 Dec;96(6):1384-1390.e4. Epub 2011 Oct 7.

Metformin reduces risk of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during gonadotropin-stimulated in vitro fertilization cycles: a randomized, controlled trial.

Palomba S, Falbo A, Carrillo L, Villani MT, Orio F, Russo T, Di Cello A, Cappiello F, Capasso S, Tolino A, Colao A, Mastrantonio P, La Sala GB, Zullo F, Cittadini E; The METformin in High Responder Italian Group.

Source

Department of Obstetrics and Gynecology, University "Magna Graecia," Catanzaro, Italy.

Abstract

OBJECTIVE:

To test whether metformin administration reduces the incidence of ovarian hyperstimulation syndrome (OHSS) in infertile high-risk patients with polycystic ovary syndrome (PCOS) who have been treated with gonadotropins for IVF.

DESIGN:

Parallel, randomized, double-blind, placebo-controlled clinical trial.

SETTING:

Academic departments, general hospital, and IVF centers.

PATIENT(S):

One hundred twenty patients with PCOS at high risk for OHSS.

INTERVENTION(S):

Gonadotropins ovarian stimulation for IVF and metformin (500 mg three times daily) or placebo tablets (three times daily).

MAIN OUTCOME MEASURE(S):

The primary end point of the current clinical trial was the rate of OHSS. Anthropometric and reproductive data were evaluated.

RESULT(S):

The total OHSS and cancellation rates were significantly reduced in patients treated with metformin. The relative risk for OHSS was of 0.28 (95% confidence interval, 0.11-0.67). With metformin the stimulation length and the total amount of gonadotropins used were significantly increased, whereas the peak E(2) levels were significantly reduced.

CONCLUSION(S):

In patients with PCOS who are at high risk for OHSS and who have been stimulated with gonadotropins for IVF cycles, metformin reduces the risk of OHSS by modulating the ovarian response to the stimulation.