卵細胞質移植可提供受體卵細胞粒腺體

將年輕卵細胞質移植到老化卵細胞之主要目的，可提供老化之受體卵細胞必要之粒腺體，提高老化卵細胞之品質與受孕率

但卵細胞質移植可能干擾卵細胞之極化過程

http://humupd.oxfordjournals.org/content/10/3/241.full

Cytoplasmic transfer in oocytes: biochemical aspects

 

Next Section

Abstract

Cytoplasmic control of preimplantation development is not a ‘new’ concept; the first cytoplasmic transfer experiment was performed in the mouse during the early 1980s, as a means of overcoming cleavage arrest at the 2‐cell stage, the ‘2‐cell block’. Since the first human pregnancy following the transfer of cytoplasm from donor oocytes into the oocytes of a patient with a history of poor embryo development and recurrent implantation failure in 1997, >30 children have been born after direct injection of ooplasm from fresh, mature or immature, or cryopreserved–thawed donor oocytes into recipient oocytes via a modified ICSI technique. Transfer of ooplasm was thus applied with astonishing speed in humans, in the absence of extensive research to evaluate the efficacy and the possible risks of the method. This review focuses on biochemical mechanisms by which transfer of ooplasm might confer a benefit: by correcting a putative imbalance between anti‐ and pro‐apoptotic factors and/or correction of defective mitochondrial membrane potential. We also emphasize the ‘empirical’ state of this technique, and the related risks.