免疫球蛋白對於反覆性流產並無明顯助益

免疫球蛋白IVIG對於反覆性流產並無明顯助益
體內具有免疫抗體之病患anti-cardiolipin antibodies，
免疫球蛋白, Heparin, aspirin, steroid並無明顯助益

http://humrep.oxfordjournals.org/content/27/12/3365.full


Unfortunately a high proportion of transferred embryos fail to implant, and there is a group of patients where implantation failure occurs repeatedly even under optimal conditions. Several strategies have been adopted to overcome recurrent implantation failure (RIF), addressing both the embryo, using techniques like assisted hatching, and the endometrium by intensifying the investigation of the female reproductive tract. The administration of intravenous immunoglobulins (IVIG) in women suspected of having an immunological cause of RIF did not improve the live birth rates when compared with placebo (Stephenson and Fluker, 2000). Similarly, in the presence of ACA (anti-cardiolipin antibodies), the use of heparin and aspirin showed no benefit (Stern et al., 2003). Attempts of administering steroids (Boomsma et al., 2007) or low-dose aspirin (Gelbaya et al., 2007) were also negative.